PH-sensitive self-repairing hydrogel and preparation method of same

The invention discloses a pH-sensitive self-repairing hydrogel and a preparation method of same. The hydrogel is produced by crosslinking dopamine-modified sodium alginate and sodium carboxymethylcellulose modified by 3-aminophenylboronic acid according to a certain ratio, wherein the modified sodium alginate and sodium carboxymethylcellulose respectively have a catechol group and a phenylboronic acid group, so that between the two groups, a pH-sensitive phenylborate bond can be formed. The phenylborate bond is fractured if pH < 7 and is recovered if pH > 7, so that the hydrogel has a pH-responded self-repairing performance. A main raw material of the hydrogel is natural polysaccharide, so that the hydrogel has excellent biocompatibility and also has pH-responding property and self-repairing performance. The hydrogel has wide applications in the fields of controllable release of drugs, tissue engineering and the like. 本发明公开了种pH敏感自修复水凝胶及其制备方法。所述水凝胶由多巴胺改性的海藻酸钠和3-氨基苯硼酸改性的羧甲基纤维素钠按照定的配比交联而成。改性后的海藻酸钠和羧甲基纤维素纳分别具有了邻苯