Recombinant complement factor H-immunoglobulin fusion protein with complement regulating activity and preparation method and application thereof

The invention discloses fusion protein CFH-Ig which is the fusion protein of a recombinant complement factor H(CFH) with complement regulating activity, especially alternative complement pathway regulating activity, and immunoglobulin (Ig). The fusion protein CFH-Ig has the complement regulating activity, especially the alternative complement pathway regulating activity, or has the effect of targeting to an abnormally-activated complement tissue at the same time. The invention further relates to a preparation method of the fusion protein and the application thereof to preparation of medicines for treating autoimmune diseases or other diseases caused by mediation, disorders or defects of an alternative complement pathway as well as thrombosis caused by excessive complement activation in human beings or other mammals. 本发明公开了种融合蛋白CFH-Ig，为具有补体调节活性尤其是补体旁路途径调节活性的重组补体因子H(CFH)和免疫球蛋白(Ig)的融合蛋白。所述融合蛋白CFH-Ig具有补体调节活性尤其是补体旁路途径调节活性，或同时具有靶向至补体异常激活组织的作用。本发明还涉及所述融合蛋白的制备方法和在制备治疗人类或者其它哺乳动物中由补体旁路途径介导、失调或缺陷所致的自身免疫性疾病或其它疾病以及因补体过度激活