Method for preparing hydroxytyrosolby utilizing organic metal compound
The invention discloses a method for preparing 4-(2-hydroxyalkyl)-1,2-benzenediol. The method comprises the following steps: (a) providing protected 1,2-benzenediol with a protected 1,2-hydroxyl group; (b) halogenating the protected 1,2-benzenediol to obtainprotected 4-halogenated-1,2-benzenediol wi...
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| creator | TAN FENGYU YANG ZHENGYI WANG XILIN |
| description | The invention discloses a method for preparing 4-(2-hydroxyalkyl)-1,2-benzenediol. The method comprises the following steps: (a) providing protected 1,2-benzenediol with a protected 1,2-hydroxyl group; (b) halogenating the protected 1,2-benzenediol to obtainprotected 4-halogenated-1,2-benzenediol with the protected 1,2-hydroxyl group; (c) in the presence of metal or organic metal compounds, performing reaction on the protected 4-halogenated-1,2-benzenediol to produce protected 4-(2-hydroxyalkyl)-1,2-benzenediolwith the protected 1,2-hydroxyl group; and (d) deprotecting the protected 4-(2-hydroxyalkyl)-1,2-benzenediol to obtain the 4-(2-hydroxyalkyl)-1,2-benzenediol. The invention also discloses application of 1,2-benzenediol to preparation of hydroxytyrosol.
本发明披露了种制备4-(2-羟烷基)-1,2-苯二酚的方法，其包括以下步骤：(a)提供具有受保护的1,2-羟基基团的受保护的1,2-苯二酚；(b)卤化所述受保护的1,2-苯二酚以获得具有受保护的所述1,2-羟基基团的受保护的4-卤代-1,2-苯二酚；(c)在金属或有机金属化合物的存在下，使所述受保护的4-卤代-1,2-苯二酚反应生成具有受保护的所述1,2-羟基基团的受保护的4-(2-羟烷基)-1,2-苯二酚；以及(d)把所述受保护的4-(2-羟烷基)-1,2-苯二酚脱保护，得到所述4-(2-羟烷基)-1, |
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本发明披露了种制备4-(2-羟烷基)-1,2-苯二酚的方法，其包括以下步骤：(a)提供具有受保护的1,2-羟基基团的受保护的1,2-苯二酚；(b)卤化所述受保护的1,2-苯二酚以获得具有受保护的所述1,2-羟基基团的受保护的4-卤代-1,2-苯二酚；(c)在金属或有机金属化合物的存在下，使所述受保护的4-卤代-1,2-苯二酚反应生成具有受保护的所述1,2-羟基基团的受保护的4-(2-羟烷基)-1,2-苯二酚；以及(d)把所述受保护的4-(2-羟烷基)-1,2-苯二酚脱保护，得到所述4-(2-羟烷基)-1,</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170707&DB=EPODOC&CC=CN&NR=106928030A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170707&DB=EPODOC&CC=CN&NR=106928030A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TAN FENGYU</creatorcontrib><creatorcontrib>YANG ZHENGYI</creatorcontrib><creatorcontrib>WANG XILIN</creatorcontrib><title>Method for preparing hydroxytyrosolby utilizing organic metal compound</title><description>The invention discloses a method for preparing 4-(2-hydroxyalkyl)-1,2-benzenediol. The method comprises the following steps: (a) providing protected 1,2-benzenediol with a protected 1,2-hydroxyl group; (b) halogenating the protected 1,2-benzenediol to obtainprotected 4-halogenated-1,2-benzenediol with the protected 1,2-hydroxyl group; (c) in the presence of metal or organic metal compounds, performing reaction on the protected 4-halogenated-1,2-benzenediol to produce protected 4-(2-hydroxyalkyl)-1,2-benzenediolwith the protected 1,2-hydroxyl group; and (d) deprotecting the protected 4-(2-hydroxyalkyl)-1,2-benzenediol to obtain the 4-(2-hydroxyalkyl)-1,2-benzenediol. The invention also discloses application of 1,2-benzenediol to preparation of hydroxytyrosol.
本发明披露了种制备4-(2-羟烷基)-1,2-苯二酚的方法，其包括以下步骤：(a)提供具有受保护的1,2-羟基基团的受保护的1,2-苯二酚；(b)卤化所述受保护的1,2-苯二酚以获得具有受保护的所述1,2-羟基基团的受保护的4-卤代-1,2-苯二酚；(c)在金属或有机金属化合物的存在下，使所述受保护的4-卤代-1,2-苯二酚反应生成具有受保护的所述1,2-羟基基团的受保护的4-(2-羟烷基)-1,2-苯二酚；以及(d)把所述受保护的4-(2-羟烷基)-1,2-苯二酚脱保护，得到所述4-(2-羟烷基)-1,</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHDzTS3JyE9RSMsvUigoSi1ILMrMS1fIqEwpyq-oLKksyi_Oz0mqVCgtyczJrAJJ5RelJ-ZlJivkppYk5igk5-cW5JfmpfAwsKYl5hSn8kJpbgZFN9cQZw_d1IL8-NTigsTk1LzUknhnP0MDM0sjCwNjA0djYtQAAMFhNL8</recordid><startdate>20170707</startdate><enddate>20170707</enddate><creator>TAN FENGYU</creator><creator>YANG ZHENGYI</creator><creator>WANG XILIN</creator><scope>EVB</scope></search><sort><creationdate>20170707</creationdate><title>Method for preparing hydroxytyrosolby utilizing organic metal compound</title><author>TAN FENGYU ; YANG ZHENGYI ; WANG XILIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN106928030A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>TAN FENGYU</creatorcontrib><creatorcontrib>YANG ZHENGYI</creatorcontrib><creatorcontrib>WANG XILIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TAN FENGYU</au><au>YANG ZHENGYI</au><au>WANG XILIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for preparing hydroxytyrosolby utilizing organic metal compound</title><date>2017-07-07</date><risdate>2017</risdate><abstract>The invention discloses a method for preparing 4-(2-hydroxyalkyl)-1,2-benzenediol. The method comprises the following steps: (a) providing protected 1,2-benzenediol with a protected 1,2-hydroxyl group; (b) halogenating the protected 1,2-benzenediol to obtainprotected 4-halogenated-1,2-benzenediol with the protected 1,2-hydroxyl group; (c) in the presence of metal or organic metal compounds, performing reaction on the protected 4-halogenated-1,2-benzenediol to produce protected 4-(2-hydroxyalkyl)-1,2-benzenediolwith the protected 1,2-hydroxyl group; and (d) deprotecting the protected 4-(2-hydroxyalkyl)-1,2-benzenediol to obtain the 4-(2-hydroxyalkyl)-1,2-benzenediol. The invention also discloses application of 1,2-benzenediol to preparation of hydroxytyrosol.
本发明披露了种制备4-(2-羟烷基)-1,2-苯二酚的方法，其包括以下步骤：(a)提供具有受保护的1,2-羟基基团的受保护的1,2-苯二酚；(b)卤化所述受保护的1,2-苯二酚以获得具有受保护的所述1,2-羟基基团的受保护的4-卤代-1,2-苯二酚；(c)在金属或有机金属化合物的存在下，使所述受保护的4-卤代-1,2-苯二酚反应生成具有受保护的所述1,2-羟基基团的受保护的4-(2-羟烷基)-1,2-苯二酚；以及(d)把所述受保护的4-(2-羟烷基)-1,2-苯二酚脱保护，得到所述4-(2-羟烷基)-1,</abstract><oa>free_for_read</oa></addata></record> |
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| title | Method for preparing hydroxytyrosolby utilizing organic metal compound |
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