Dexlansoprazole crystal form and preparation method

Dexlansoprazole crystal form and preparation method

The invention belongs to the technical field of medicines and in particular relates to a dexlansoprazole crystal form and a preparation method. A dexlansoprazole crystal with good heat stability is obtained through a method comprising the steps of culturing a crystal nucleus and slowly crystallizing...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: LYU XIUSHENG, XIA JUN, KONG LEI
Format: Patent
Sprache:chi ; eng
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator LYU XIUSHENG
XIA JUN
KONG LEI
description The invention belongs to the technical field of medicines and in particular relates to a dexlansoprazole crystal form and a preparation method. A dexlansoprazole crystal with good heat stability is obtained through a method comprising the steps of culturing a crystal nucleus and slowly crystallizing. The preparation method comprises the following steps: dissolving an anhydrous dexlansoprazole crude product into acetone and de-coloring with active carbon; dropwise adding one part of isopropyl ether at 20 DEG C to 25 DEG C; stirring and culturing a crystal; culturing the crystal nucleus; then slowly dropwise adding the other part of isopropyl ether; filtering and drying to obtain a product. The product prepared by the method provided by the invention is good in heat stability and slow in degradation speed; the problems of degradation, color change and the like during a storage process of the dexlansoprazole are effectively solved; the solubility and dissolvability of the product prepared by the method are also
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN106866631A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN106866631A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN106866631A3</originalsourceid><addsrcrecordid>eNrjZDB2Sa3IScwrzi8oSqzKz0lVSC6qLC5JzFFIyy_KVUjMS1EoKEotSCxKLMnMz1PITS3JyE_hYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GBmYWZmZmxoaOxsSoAQBHti0O</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Dexlansoprazole crystal form and preparation method</title><source>esp@cenet</source><creator>LYU XIUSHENG ; XIA JUN ; KONG LEI</creator><creatorcontrib>LYU XIUSHENG ; XIA JUN ; KONG LEI</creatorcontrib><description>The invention belongs to the technical field of medicines and in particular relates to a dexlansoprazole crystal form and a preparation method. A dexlansoprazole crystal with good heat stability is obtained through a method comprising the steps of culturing a crystal nucleus and slowly crystallizing. The preparation method comprises the following steps: dissolving an anhydrous dexlansoprazole crude product into acetone and de-coloring with active carbon; dropwise adding one part of isopropyl ether at 20 DEG C to 25 DEG C; stirring and culturing a crystal; culturing the crystal nucleus; then slowly dropwise adding the other part of isopropyl ether; filtering and drying to obtain a product. The product prepared by the method provided by the invention is good in heat stability and slow in degradation speed; the problems of degradation, color change and the like during a storage process of the dexlansoprazole are effectively solved; the solubility and dissolvability of the product prepared by the method are also</description><language>chi ; eng</language><subject>APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20170620&amp;DB=EPODOC&amp;CC=CN&amp;NR=106866631A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20170620&amp;DB=EPODOC&amp;CC=CN&amp;NR=106866631A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LYU XIUSHENG</creatorcontrib><creatorcontrib>XIA JUN</creatorcontrib><creatorcontrib>KONG LEI</creatorcontrib><title>Dexlansoprazole crystal form and preparation method</title><description>The invention belongs to the technical field of medicines and in particular relates to a dexlansoprazole crystal form and a preparation method. A dexlansoprazole crystal with good heat stability is obtained through a method comprising the steps of culturing a crystal nucleus and slowly crystallizing. The preparation method comprises the following steps: dissolving an anhydrous dexlansoprazole crude product into acetone and de-coloring with active carbon; dropwise adding one part of isopropyl ether at 20 DEG C to 25 DEG C; stirring and culturing a crystal; culturing the crystal nucleus; then slowly dropwise adding the other part of isopropyl ether; filtering and drying to obtain a product. The product prepared by the method provided by the invention is good in heat stability and slow in degradation speed; the problems of degradation, color change and the like during a storage process of the dexlansoprazole are effectively solved; the solubility and dissolvability of the product prepared by the method are also</description><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB2Sa3IScwrzi8oSqzKz0lVSC6qLC5JzFFIyy_KVUjMS1EoKEotSCxKLMnMz1PITS3JyE_hYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GBmYWZmZmxoaOxsSoAQBHti0O</recordid><startdate>20170620</startdate><enddate>20170620</enddate><creator>LYU XIUSHENG</creator><creator>XIA JUN</creator><creator>KONG LEI</creator><scope>EVB</scope></search><sort><creationdate>20170620</creationdate><title>Dexlansoprazole crystal form and preparation method</title><author>LYU XIUSHENG ; XIA JUN ; KONG LEI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN106866631A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LYU XIUSHENG</creatorcontrib><creatorcontrib>XIA JUN</creatorcontrib><creatorcontrib>KONG LEI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LYU XIUSHENG</au><au>XIA JUN</au><au>KONG LEI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Dexlansoprazole crystal form and preparation method</title><date>2017-06-20</date><risdate>2017</risdate><abstract>The invention belongs to the technical field of medicines and in particular relates to a dexlansoprazole crystal form and a preparation method. A dexlansoprazole crystal with good heat stability is obtained through a method comprising the steps of culturing a crystal nucleus and slowly crystallizing. The preparation method comprises the following steps: dissolving an anhydrous dexlansoprazole crude product into acetone and de-coloring with active carbon; dropwise adding one part of isopropyl ether at 20 DEG C to 25 DEG C; stirring and culturing a crystal; culturing the crystal nucleus; then slowly dropwise adding the other part of isopropyl ether; filtering and drying to obtain a product. The product prepared by the method provided by the invention is good in heat stability and slow in degradation speed; the problems of degradation, color change and the like during a storage process of the dexlansoprazole are effectively solved; the solubility and dissolvability of the product prepared by the method are also</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language chi ; eng
recordid cdi_epo_espacenet_CN106866631A
source esp@cenet
subjects APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Dexlansoprazole crystal form and preparation method
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T16%3A10%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LYU%20XIUSHENG&rft.date=2017-06-20&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN106866631A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true