Dexlansoprazole crystal form and preparation method

The invention belongs to the technical field of medicines and in particular relates to a dexlansoprazole crystal form and a preparation method. A dexlansoprazole crystal with good heat stability is obtained through a method comprising the steps of culturing a crystal nucleus and slowly crystallizing...

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Hauptverfasser: LYU XIUSHENG, XIA JUN, KONG LEI
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention belongs to the technical field of medicines and in particular relates to a dexlansoprazole crystal form and a preparation method. A dexlansoprazole crystal with good heat stability is obtained through a method comprising the steps of culturing a crystal nucleus and slowly crystallizing. The preparation method comprises the following steps: dissolving an anhydrous dexlansoprazole crude product into acetone and de-coloring with active carbon; dropwise adding one part of isopropyl ether at 20 DEG C to 25 DEG C; stirring and culturing a crystal; culturing the crystal nucleus; then slowly dropwise adding the other part of isopropyl ether; filtering and drying to obtain a product. The product prepared by the method provided by the invention is good in heat stability and slow in degradation speed; the problems of degradation, color change and the like during a storage process of the dexlansoprazole are effectively solved; the solubility and dissolvability of the product prepared by the method are also