Preparation method of 2-fluoro-2-alkyloxy trifluoropropionate

The invention discloses a preparation method of 2-fluoro-2-alkyloxy trifluoropropionate. In the presence of an organic alkali and/or an inorganic alkali, hexafluoropropylene oxide and alkyl alcohols carry out reactions to obtain corresponding 2-fluoro-2-alkyloxy trifluoropropionate. The provided method has the advantages of suitable reaction temperature, high reaction yield, good selectivity, little amount of waste solid, waste water, and waste gas, and easiness for industrialization. The prepared 2-fluoro-2-alkyloxy trifluoropropionate can be used as a trifluoromethylation reagent for the synthesis of novel medicines and pesticides. 本发明公开了种制备2-氟-2-烷氧基三氟丙酸酯的方法，通过在有机碱和/或无机碱催化作用下，六氟环氧丙烷与烷基醇反应得到相应的2-氟-2-烷氧基三氟丙酸酯。本发明提供的方法反应温度合适、反应收率高、选择性好，三废量少和易于工业化。制备的2-氟-2-烷氧基三氟丙酸酯适合作为三氟甲基化试剂用于新代医药、农药的合成。