Sildenafil citrate smell masking resin compound and application thereof

The invention discloses a sildenafil citrate smell masking resin compound and application thereof, and aims at solving the technical problems to shield the bad smell of the medicine active ingredient of sildenafil citrate, so that good mouthfeel can be realized. The medicine smell masking resin comp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: ZHANG SHAN, HAN XIAOPENG, YIN LIFANG, QIN CHAO, ZHU CHUNLI, DONG YANGYU
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a sildenafil citrate smell masking resin compound and application thereof, and aims at solving the technical problems to shield the bad smell of the medicine active ingredient of sildenafil citrate, so that good mouthfeel can be realized. The medicine smell masking resin compound is prepared from sildenafil citrate and acid type cation exchange resin through a static exchange method; the weight ratio of the sildenafil citrate to the acid type cation exchange resin is 0.5:1 to 3:1. The prepared sildenafil citrate smell masking resin compound can be further prepared into chewable tablets, orally disintegrating tablets, granules and suspensions. Compared with the prior art, the sildenafil citrate smell masking resin compound has the advantages that an ion exchange technology is used; the bad smell of the sildenafil citrate can be effectively shielded; the patient compliance is improved; the preparation process is simple; the sildenafil citrate smell masking resin compound is suitable for