Extraction process for producing 11alpha,17alpha-dihydroxy progesterone by bioconversion of 17alpha-hydroxyl progesterone

The invention discloses an extraction process for producing 11alpha,17alpha-dihydroxy progesterone by bioconversion of 17alpha-hydroxyl progesterone. The process mainly comprises the steps of solid-liquid separation of fermentation broth, collection of an aqueous product, extraction, concentration, crystallization, recrystallization and drying. The obtained 11alpha,17alpha-dihydroxy progesterone has the purity of more than or equal to 99 percent and the yield of more than or equal to 95 percent. The process has the characteristics of process simplicity and high product purity. 本发明公开了种生物转化17α-羟基黄体酮生产11α,17α-双羟基黄体酮的提取工艺。本工艺主要步骤包括发酵液固液分离、收集水相产物、萃取、浓缩、结晶、重结晶和干燥，所得11α,17α-双羟基黄体酮的纯度≥99％，收率≥95％。本方法具有工艺简单，产品纯度高的特点。