Preparation method of rabbit retinitis pigmentosa model

The invention discloses a preparation method of a rabbit retinitis pigmentosa model. The preparation method includes steps of applying a certain concentration and dosage of sodium iodate to a rabbit through a method of carotid artery injection, so that the sodium iodate reaches the rabbit's eyes. Through above method, the sodium iodate dosage is few, and toxicity to the whole animal body is small, the animal life safety is not influenced; the method is simple and feasible, good in repeatability, small in individual model difference, and high in success rate. The preparation method provides a reliable model for the study of the retinitis pigmentosa, and also provides an animal model for the drug research and development and preclinical evaluation for treating retinitis pigmentosa. 本发明公开了种兔的视网膜色素变性模型的制备方法，包括步骤为：将定浓度和剂量的碘酸钠以颈动脉注入的方式实施于兔，所述碘酸钠溶液到达兔的眼内。通过上述方式，本发明使用的碘酸钠剂量小，对动物全身毒性小，不影响动物生命安全，操作简单可行，可重复性好，个体间模型差异小，成功率高。能为视网膜色素变性的研究提供种可靠的模型，同时为治疗视网膜色素变性药物研发和临床前评价提供了动物模型。