Microorganisms and methods for the production of fatty acids and fatty acid derived products

This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a fatty acid or fatty acid derived product, wherein the modified microorganism produces fatty acyl-CoA intermediates via a...

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Bibliographische Detailangaben
Hauptverfasser:	LIPSCOMB MATTHEW, LIPSCOMB TANYA, EVANS RON, LIAO HANS, PRATHER BRITTANY, COPLEY SHELLEY, SPINDLER EILEEN, LOUIE MICHAEL, LYNCH MICHAEL, HOGSETT DAVE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a fatty acid or fatty acid derived product, wherein the modified microorganism produces fatty acyl-CoA intermediates via a malonyl-CoA dependent but malonyl-ACP independent mechanism. 本发明涉及经代谢改造的微生物菌株，例如细菌菌株，在所述菌株中，提高了丙二酰辅酶A的利用率，以产生脂肪酸或脂肪酸衍生产物，其中所述经修饰微生物利用依赖丙二酰辅酶A、但不依赖丙二酰-ACP的机理产生脂肪酰辅酶A中间体。