Indole derivative with 1, 2, 4-oxadiazole structure, preparation method thereof and application thereof in preparation of antibacterial medicines

The invention discloses an indole derivative with a 1, 2, 4-oxadiazole structure, which has antibacterial activity, a preparation method thereof and application thereof in preparation of antibacterial medicines, belonging to the technical field of medicine synthesis. The compound has the structure as shown in the general formula I, wherein when an A ring is an aromatic ring, R1 and R2 are ortho-positions, meta-positions and para-substituted groups on the aromatic ring; and when the an A ring is a non-aromatic ring, both the R1 and R2 are hydrogen. The compound disclosed by the invention is a novel alkaloid compound which is synthesized for the first time; and the compound has certain inhibitory activity on methicillin-resistant staphylococcus aureus (MRSA), which is found for the first time in synthetic compound in vitro model testing experiments, and therefore, the compound has potential application prospects in preparation of antibacterial medicines and treatment of bacterial infection. 本发明公开了种具有抗菌活性的1,2,4-