Beta-ionone substituted curcumin analogue as well as preparation method and application of beta-ionone substituted curcumin analogue

The invention discloses a beta-ionone substituted curcumin analogue as well as a preparation method and application of the beta-ionone substituted curcumin analogue. The structure of the curcumin analogue is shown as a formula (I), wherein R is substituted or unsubstituted phenyl and substituted or unsubstituted heteroaryl; a substituent group on the phenyl or the heteroaryl is selected from one or more of alkyl, alkoxyl, halogen, nitryl and dialkyl amine. A pharmacological effect test proves that a beta-ionone segment is introduced into a parent structure of curcumin, so that the anti-inflammatory activity of the compound can be remarkably improved, levels of TNF-alpha (Tumor Necrosis Factor-alpha) and IL-6 (Interleukin-6) are reduced and the probability of occurrence of infectious shock is reduced. (The formula (I) is shown in the description.). 本发明公开了种由β-紫罗兰酮取代的姜黄素类似物及其制备方法和应用，该姜黄素类似物的结构如式(I)所示，其中，R为取代或者未取代的苯基、取代或者未取代的杂芳基；所述的苯基或者杂芳基上的取代基选自个或者多个烷基、烷氧基、卤素、硝基或二烷基胺。药效试验表明，在姜黄素的母体结构上引入β-紫罗兰酮片段，可以明显提升这类化合物的抗炎活性，