Compound preparation containing lovastatin, fenofibrate and acipimox, and preparation method of compound preparation
The invention provides a compound preparation containing lovastatin, fenofibrate and acipimox. The compound preparation is mainly prepared from the lovastatin, the fenofibrate, the acipimox and a pharmaceutically acceptable carrier A. The solubility problem of the lovastatin and the fenofibrate is f...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention provides a compound preparation containing lovastatin, fenofibrate and acipimox. The compound preparation is mainly prepared from the lovastatin, the fenofibrate, the acipimox and a pharmaceutically acceptable carrier A. The solubility problem of the lovastatin and the fenofibrate is firstly solved by means of a solid dispersion technology. Furthermore, the drug release speeds of the three active ingredients, i.e., the lovastatin, the fenofibrate and the acipimox are regulated and controlled by using a slow release method, so that the plasma concentrations of the lovastatin, the fenofibrate and the acipimox are enabled to be stable, the phenomenon of plasma concentration crest-trough is avoided, and the adverse drug reactions are further reduced; the synergistic effect of the lovastatin, the fenofibrate and the acipimox is exerted, so that the curative effect is facilitated to be improved. The stable effects of reducing blood pressure and blood fat can be achieved in one day only by taking the c |
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