Hyaluronic acid nanometer vesicle, and preparation method and application thereof

The invention relates to a hyaluronic acid nanometer vesicle, and a preparation method and application thereof, which can effectively solve the preparation problem of the hyaluronic acid nanometer vesicle, and realizes the application in tumor gene therapy drugs. The hyaluronic acid nanometer vesicle is characterized in that hyaluronic acid is a functional long chain grafted through a chemical bond, polyethyleneimine is grafted to the tail end of the functional long chain, when being interacted with nucleic acid, the polyethyleneimine compresses the nucleic acid through electrostatic interaction, and the hyaluronic acid fully wraps the periphery of the polyethyleneimine/nucleic acid to form a vesicle structure. The raw material source is wide, the preparation method is simple, the cost is low, and the prepared hyaluronic acid nanometer vesicle is regular in morphology, has the particle size range ranging from 100 to 300nm, is stable in structure, uniform in distribution, good in biocompatibility and low in vi