Pancreatic kallidinogenase enteric-coated tablet and process study thereof

The invention discloses process study of a pancreatic kallidinogenase enteric-coated tablet. According to the technical scheme, polyvinylpyrrolidone is adopted as a binding agent of the pancreatic kallidinogenase enteric-coated tablet, the pancreatic kallidinogenase enteric-coated tablet with short disintegration time can be obtained, and prescription (1000 tablets) of the pancreatic kallidinogenase enteric-coated tablet is as follows: 185 thousands units of kallidinogenase, 50.0g of microcrystalline cellulose, 30.0g of pregelatinized starch, 90.0g of lactose, 25ml of polyvinylpyrrolidone, right amount of purified water and 0.5g of magnesium stearate. 本发明公开了种胰激肽原酶肠溶片工艺研究，技术方案是采用聚乙烯吡咯烷酮作为胰激肽原酶肠溶片的粘合剂，能得到崩解时间短的胰激肽原酶肠溶片，其处方如下（1000片）：胰激肽原酶18.5万单位；微晶纤维素50.0g；预胶化淀粉30.0g；乳糖90.0g；聚乙烯吡咯酮25ml；纯化水适量；硬脂酸镁0.5g。