Microbiological process

A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolating an imino sugar produced by said microorganism, and the micr...

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Bibliographische Detailangaben
Hauptverfasser:	VAZQUEZ MUNIZ MARIA JESUS, FOSBERRY ANDREW PETER, ALVAREZ-RUIZ EMILIO, DANN ALISON SARAH, READY SARAH JANE, COLLIS ANDREW JOHN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolating an imino sugar produced by said microorganism, and the microorganisms used in this process. The invention also comprises migalastat produced according to the above method and pharmaceutical compositions and uses thereof. 用于微生物合成米加司他的方法，尤其是米加司他的生产方法，其包含在能生产至少种亚胺糖的条件下培养微生物，以及检测和/或分离所述微生物产生的亚胺糖，以及本方法中使用的微生物。本发明还包括根据上述方法生产的米加司他和药物组合物及其用途。