Peptides as well as pharmaceutical composition and application thereof

The invention provides a group of peptides as well as a pharmaceutical composition and application thereof. The peptides are as shown in sequence tables; the peptides have amino acid sequences with an analgesic effect, or are pharmacologically acceptable salts of the peptides. A ring is formed by two cysteines at the head end and the tail end of each peptide. A pharmacophore (a structural domain) which has abirritation in the GsMTx-4 peptide is determined by comparing multiple inhibitor cystein knot (ICK)-containing peptide sequences such as GsMTx-4 and GsMTX-2 and carrying out behavior test on a rat pain model. 本发明提供了组肽及其药物组合物和应用，其中肽如序列表所示，其是具有镇痛作用的氨基酸序列或它们药学上可以接受的盐。提供肽的首端和末端的两个半胱氨酸形成环。本发明通过比较GsMTx-4、GsMTX-2等多种含半胱氨酸结(ICK)的多肽序列,并通过对大鼠疼痛模型的行为学检测,确定了在GsMTx-4多肽中起镇痛作用的药效团(结构域)。