(S)-pantoprazole preparation method
The invention discloses a (S)-pantoprazole preparation method. The preparation method includes: in an organic solvent, subjecting pantoprazole thioether as shown in a formula I to contact reaction with N-methyl-N-morpholine oxide in existence of chiral quaternary ammonium salt to obtain (S)-pantopra...
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| creator | XU SHINA |
| description | The invention discloses a (S)-pantoprazole preparation method. The preparation method includes: in an organic solvent, subjecting pantoprazole thioether as shown in a formula I to contact reaction with N-methyl-N-morpholine oxide in existence of chiral quaternary ammonium salt to obtain (S)-pantoprazole. By adoption of the (S)-pantoprazole preparation method, wild conditions, high product yield and high selectivity are realized, generation of excessive oxidation products is avoided, and accordingly aftertreatment is simpler. In addition, the (S)-pantoprazole preparation method is high in conditional response efficiency, and reaction time is greatly shortened.
本发明公开了种(S)-泮托拉唑的制备方法，其中，该制备方法包括：在有机溶剂中，在手性季铵盐存在下，将式I所示的泮托拉唑硫醚与N-甲基-N-氧化吗啉接触反应得到(S)-泮托拉唑，采用本发明提供的(S)-泮托拉唑的制备方法，条件温和，产物收率更高，选择性更好，并且不会产生过度氧化产物，使得后处理更加简单，另外，本发明的条件反应效率更高，反应时间也大大缩短。 |
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本发明公开了种(S)-泮托拉唑的制备方法，其中，该制备方法包括：在有机溶剂中，在手性季铵盐存在下，将式I所示的泮托拉唑硫醚与N-甲基-N-氧化吗啉接触反应得到(S)-泮托拉唑，采用本发明提供的(S)-泮托拉唑的制备方法，条件温和，产物收率更高，选择性更好，并且不会产生过度氧化产物，使得后处理更加简单，另外，本发明的条件反应效率更高，反应时间也大大缩短。</description><language>chi ; eng</language><subject>APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170510&DB=EPODOC&CC=CN&NR=106632251A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170510&DB=EPODOC&CC=CN&NR=106632251A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XU SHINA</creatorcontrib><title>(S)-pantoprazole preparation method</title><description>The invention discloses a (S)-pantoprazole preparation method. The preparation method includes: in an organic solvent, subjecting pantoprazole thioether as shown in a formula I to contact reaction with N-methyl-N-morpholine oxide in existence of chiral quaternary ammonium salt to obtain (S)-pantoprazole. By adoption of the (S)-pantoprazole preparation method, wild conditions, high product yield and high selectivity are realized, generation of excessive oxidation products is avoided, and accordingly aftertreatment is simpler. In addition, the (S)-pantoprazole preparation method is high in conditional response efficiency, and reaction time is greatly shortened.
本发明公开了种(S)-泮托拉唑的制备方法，其中，该制备方法包括：在有机溶剂中，在手性季铵盐存在下，将式I所示的泮托拉唑硫醚与N-甲基-N-氧化吗啉接触反应得到(S)-泮托拉唑，采用本发明提供的(S)-泮托拉唑的制备方法，条件温和，产物收率更高，选择性更好，并且不会产生过度氧化产物，使得后处理更加简单，另外，本发明的条件反应效率更高，反应时间也大大缩短。</description><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFDWCNbULUjMK8kvKEqsys9JVSgoSi1ILEosyczPU8hNLcnIT-FhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGZmbGRkamho7GxKgBANQ5JlQ</recordid><startdate>20170510</startdate><enddate>20170510</enddate><creator>XU SHINA</creator><scope>EVB</scope></search><sort><creationdate>20170510</creationdate><title>(S)-pantoprazole preparation method</title><author>XU SHINA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN106632251A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>XU SHINA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XU SHINA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>(S)-pantoprazole preparation method</title><date>2017-05-10</date><risdate>2017</risdate><abstract>The invention discloses a (S)-pantoprazole preparation method. The preparation method includes: in an organic solvent, subjecting pantoprazole thioether as shown in a formula I to contact reaction with N-methyl-N-morpholine oxide in existence of chiral quaternary ammonium salt to obtain (S)-pantoprazole. By adoption of the (S)-pantoprazole preparation method, wild conditions, high product yield and high selectivity are realized, generation of excessive oxidation products is avoided, and accordingly aftertreatment is simpler. In addition, the (S)-pantoprazole preparation method is high in conditional response efficiency, and reaction time is greatly shortened.
本发明公开了种(S)-泮托拉唑的制备方法，其中，该制备方法包括：在有机溶剂中，在手性季铵盐存在下，将式I所示的泮托拉唑硫醚与N-甲基-N-氧化吗啉接触反应得到(S)-泮托拉唑，采用本发明提供的(S)-泮托拉唑的制备方法，条件温和，产物收率更高，选择性更好，并且不会产生过度氧化产物，使得后处理更加简单，另外，本发明的条件反应效率更高，反应时间也大大缩短。</abstract><oa>free_for_read</oa></addata></record> |
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| title | (S)-pantoprazole preparation method |
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