(S)-pantoprazole preparation method

The invention discloses a (S)-pantoprazole preparation method. The preparation method includes: in an organic solvent, subjecting pantoprazole thioether as shown in a formula I to contact reaction with N-methyl-N-morpholine oxide in existence of chiral quaternary ammonium salt to obtain (S)-pantoprazole. By adoption of the (S)-pantoprazole preparation method, wild conditions, high product yield and high selectivity are realized, generation of excessive oxidation products is avoided, and accordingly aftertreatment is simpler. In addition, the (S)-pantoprazole preparation method is high in conditional response efficiency, and reaction time is greatly shortened. 本发明公开了种(S)-泮托拉唑的制备方法，其中，该制备方法包括：在有机溶剂中，在手性季铵盐存在下，将式I所示的泮托拉唑硫醚与N-甲基-N-氧化吗啉接触反应得到(S)-泮托拉唑，采用本发明提供的(S)-泮托拉唑的制备方法，条件温和，产物收率更高，选择性更好，并且不会产生过度氧化产物，使得后处理更加简单，另外，本发明的条件反应效率更高，反应时间也大大缩短。