Lappaconitine aza-cinnamic acid heterozygote with antitumor activity and synthesis method of lappaconitine aza-cinnamic acid heterozygote

The invention discloses a lappaconitine aza-cinnamic acid heterozygote with antitumor activity and a synthesis method of the lappaconitine aza-cinnamic acid heterozygote. Lappaconitine, aza-cinnamic acid and derivatives thereof are taken as raw materials to synthesize unreported lappaconitine aza-cinnamic acid amide compounds. The synthesis method is high in operation safety, mild in reaction condition and suitable for industrial production. According to preliminary biological activity test, the compounds are high in antitumor activity and can be used for researching of antitumor lead compounds. 种具抗肿瘤活性的高乌甲素氮杂肉桂酸杂合体及其合成方法，该类化合物以高乌甲素、氮杂肉桂酸及其衍生物为原料,合成了类未见报道的高乌甲素氮杂肉桂酸酰胺类化合物。该类化合物合成方法操作安全性高,反应条件温和,适用于工业化生产，经初步生物活性测试表明该类型化合物有较好的抗肿瘤活性,可用于抗肿瘤先导化合物的研究。