Fluorine-containing water-soluble platinum complex and its preparation method and use

The invention discloses a fluorine-containing water-soluble platinum complex and its preparation method and use. The fluorine-containing water-soluble platinum complex is shown in the formula (I). The fluorine-containing water-soluble platinum complex has excellent tumor-selective drug accumulation...

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Hauptverfasser: LIU RAN, LIU PENGXING, MI QIAN, HAN JIANBIN, GAO XIANGQIAN, GAO QINGZHI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a fluorine-containing water-soluble platinum complex and its preparation method and use. The fluorine-containing water-soluble platinum complex is shown in the formula (I). The fluorine-containing water-soluble platinum complex has excellent tumor-selective drug accumulation effects and prevents rejection-caused tumor resistance to drugs by targeting delivery to tumor cells. Compared with clinical drugs, the complex has high water solubility and is suitable for clinical preparation. Compared with a clinical drug oxaliplatin, the complex has superiority in cytotoxicity. The fluorine-containing water-soluble platinum complex solves the problem the existing platinum drug has poor water solubility, poor stability and clinical use inconvenience, improves drug targeting effects on tumor cells, and solves the problem that the existing clinical drugs has deficiency in tumor treatment effects, resistance to drugs and toxic or side effect. 本发明公开了含氟水溶性铂配合物及制备方法及用途,含氟水溶性铂配合物,是式(I)所示:本发明的含氟水溶性铂配合物具