Catalyst for reduction of aromatic nitro in synthesis of triptan-based drug intermediate and preparation method of catalyst

The invention discloses a catalyst for reduction of aromatic nitro in synthesis of triptan-based drug intermediate. The catalyst is an NixPd(1 x)@PEI GNs nanocomposite catalyst which is formed by using alloy nanoparticles composed of metals Ni and Pd as active components and using polyethyleneimine...

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Bibliographische Detailangaben
Hauptverfasser: YAO JUYING, XIA KEJIAN, LUO MINGHONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a catalyst for reduction of aromatic nitro in synthesis of triptan-based drug intermediate. The catalyst is an NixPd(1 x)@PEI GNs nanocomposite catalyst which is formed by using alloy nanoparticles composed of metals Ni and Pd as active components and using polyethyleneimine functionalized graphene as a carrier, and is obtained by using sodium borohydride as a reducing agent for co-reducing precursors of active metals Ni and Pd and the carrier polyethyleneimine functionalized graphene. The nanocomposite catalyst provided by the invention is prepared according to a co-reduction method which is simple in operation and high in reliability, has excellent catalysis performance for the reduction of aromatic nitro, and can completely catalyze aromatic nitro and reduce into aromatic amino; the conversion rate of aromatic nitro compound is 99.9%; the catalyst prepared in the invention can also be used repeatedly, and is cheap, efficient, easy to recycle, environmentally friendly and suitable fo