Preparation method for ultrasonic fluorescence bimodal nano-probe for recognizing unstable plaque of atherosclerosis

The invention relates to the field of an ultrasonic molecular probe and especially relates to an ultrasonic fluorescence bimodal nano-probe for recognizing unstable plaque of atherosclerosis, a preparation method and an application thereof. An ultrasonic fluorescence molecular probe comprises an antibody, an ultrasound contrast group and a fluorophore, wherein the ultrasound contrast group is linked with a mercapto group of the antibody; the fluorophore is linked with a free amino group of the antibody; the ultrasound contrast group is covalently linked with the mercapto group of the antibody through a carbon-sulfur bond; the fluorophore is covalently linked with the antibody through an amido bond. According to the invention, a diagnostic method for the plaque of atherosclerosis is enriched. An ultrasonic fluorescence bimodal imaging technique is adopted for recognizing a vulnerable plaque, so that the cardiovascular event can be early prevented. 本发明涉及超声分子探针领域，尤其涉及种用于动脉粥样硬化不稳定斑块识别的超声荧光双模态分子探针及其制备方法和应用。种超声荧光分子