Freeze-drying process of thymalfasin for injection

Freeze-drying process of thymalfasin for injection

The invention discloses a freeze-drying process of thymalfasin for injection. The freeze-drying process is characterized by including the first step of pre-freezing, the second step of primary sublimation drying and the third step of secondary sublimation drying. In the second step of primary sublim...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: LIU YUANZHENG, OUYANG JIAN, WANG LIANGYOU, GU SHIPING, SHEN YUNFENG
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator LIU YUANZHENG
OUYANG JIAN
WANG LIANGYOU
GU SHIPING
SHEN YUNFENG
description The invention discloses a freeze-drying process of thymalfasin for injection. The freeze-drying process is characterized by including the first step of pre-freezing, the second step of primary sublimation drying and the third step of secondary sublimation drying. In the second step of primary sublimation drying, seven-stage step temperature rise is adopted, wherein a, a coolant is heated to -10 DEG C+/-1 DEG C, and heat preservation is conducted for 1-1.5 h; when the vacuum degree reaches 15 Pa+/-3 Pa, automatic pulsed gas infiltration is conducted, and when the vacuum degree reaches 25 Pa+/-5 Pa, gas infiltration is stopped; b, the coolant is heated to -5 DEG C+/-1 DEG C, heat preservation is conducted for 1-1.5 h, and gas infiltration is conducted till the vacuum degree reaches 25 Pa+/-5 Pa; c, the coolant is heated to 0 DEG C+/-1 DEG C, heat preservation is conducted, and gas infiltration is conducted till the vacuum degree reaches 25 Pa+/-5 Pa; d, the coolant is heated to 5 DEG C+/-1 DEG C, heat preservat
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN106581644A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN106581644A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN106581644A3</originalsourceid><addsrcrecordid>eNrjZDByK0pNrUrVTSmqzMxLVygoyk9OLS5WyE9TKMmozE3MSUsszsxTSMsvUsjMy0pNLsnMz-NhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGZqYWhmYmJo7GxKgBAOcFLFg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Freeze-drying process of thymalfasin for injection</title><source>esp@cenet</source><creator>LIU YUANZHENG ; OUYANG JIAN ; WANG LIANGYOU ; GU SHIPING ; SHEN YUNFENG</creator><creatorcontrib>LIU YUANZHENG ; OUYANG JIAN ; WANG LIANGYOU ; GU SHIPING ; SHEN YUNFENG</creatorcontrib><description>The invention discloses a freeze-drying process of thymalfasin for injection. The freeze-drying process is characterized by including the first step of pre-freezing, the second step of primary sublimation drying and the third step of secondary sublimation drying. In the second step of primary sublimation drying, seven-stage step temperature rise is adopted, wherein a, a coolant is heated to -10 DEG C+/-1 DEG C, and heat preservation is conducted for 1-1.5 h; when the vacuum degree reaches 15 Pa+/-3 Pa, automatic pulsed gas infiltration is conducted, and when the vacuum degree reaches 25 Pa+/-5 Pa, gas infiltration is stopped; b, the coolant is heated to -5 DEG C+/-1 DEG C, heat preservation is conducted for 1-1.5 h, and gas infiltration is conducted till the vacuum degree reaches 25 Pa+/-5 Pa; c, the coolant is heated to 0 DEG C+/-1 DEG C, heat preservation is conducted, and gas infiltration is conducted till the vacuum degree reaches 25 Pa+/-5 Pa; d, the coolant is heated to 5 DEG C+/-1 DEG C, heat preservat</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20170426&amp;DB=EPODOC&amp;CC=CN&amp;NR=106581644A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20170426&amp;DB=EPODOC&amp;CC=CN&amp;NR=106581644A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU YUANZHENG</creatorcontrib><creatorcontrib>OUYANG JIAN</creatorcontrib><creatorcontrib>WANG LIANGYOU</creatorcontrib><creatorcontrib>GU SHIPING</creatorcontrib><creatorcontrib>SHEN YUNFENG</creatorcontrib><title>Freeze-drying process of thymalfasin for injection</title><description>The invention discloses a freeze-drying process of thymalfasin for injection. The freeze-drying process is characterized by including the first step of pre-freezing, the second step of primary sublimation drying and the third step of secondary sublimation drying. In the second step of primary sublimation drying, seven-stage step temperature rise is adopted, wherein a, a coolant is heated to -10 DEG C+/-1 DEG C, and heat preservation is conducted for 1-1.5 h; when the vacuum degree reaches 15 Pa+/-3 Pa, automatic pulsed gas infiltration is conducted, and when the vacuum degree reaches 25 Pa+/-5 Pa, gas infiltration is stopped; b, the coolant is heated to -5 DEG C+/-1 DEG C, heat preservation is conducted for 1-1.5 h, and gas infiltration is conducted till the vacuum degree reaches 25 Pa+/-5 Pa; c, the coolant is heated to 0 DEG C+/-1 DEG C, heat preservation is conducted, and gas infiltration is conducted till the vacuum degree reaches 25 Pa+/-5 Pa; d, the coolant is heated to 5 DEG C+/-1 DEG C, heat preservat</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDByK0pNrUrVTSmqzMxLVygoyk9OLS5WyE9TKMmozE3MSUsszsxTSMsvUsjMy0pNLsnMz-NhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGZqYWhmYmJo7GxKgBAOcFLFg</recordid><startdate>20170426</startdate><enddate>20170426</enddate><creator>LIU YUANZHENG</creator><creator>OUYANG JIAN</creator><creator>WANG LIANGYOU</creator><creator>GU SHIPING</creator><creator>SHEN YUNFENG</creator><scope>EVB</scope></search><sort><creationdate>20170426</creationdate><title>Freeze-drying process of thymalfasin for injection</title><author>LIU YUANZHENG ; OUYANG JIAN ; WANG LIANGYOU ; GU SHIPING ; SHEN YUNFENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN106581644A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU YUANZHENG</creatorcontrib><creatorcontrib>OUYANG JIAN</creatorcontrib><creatorcontrib>WANG LIANGYOU</creatorcontrib><creatorcontrib>GU SHIPING</creatorcontrib><creatorcontrib>SHEN YUNFENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU YUANZHENG</au><au>OUYANG JIAN</au><au>WANG LIANGYOU</au><au>GU SHIPING</au><au>SHEN YUNFENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Freeze-drying process of thymalfasin for injection</title><date>2017-04-26</date><risdate>2017</risdate><abstract>The invention discloses a freeze-drying process of thymalfasin for injection. The freeze-drying process is characterized by including the first step of pre-freezing, the second step of primary sublimation drying and the third step of secondary sublimation drying. In the second step of primary sublimation drying, seven-stage step temperature rise is adopted, wherein a, a coolant is heated to -10 DEG C+/-1 DEG C, and heat preservation is conducted for 1-1.5 h; when the vacuum degree reaches 15 Pa+/-3 Pa, automatic pulsed gas infiltration is conducted, and when the vacuum degree reaches 25 Pa+/-5 Pa, gas infiltration is stopped; b, the coolant is heated to -5 DEG C+/-1 DEG C, heat preservation is conducted for 1-1.5 h, and gas infiltration is conducted till the vacuum degree reaches 25 Pa+/-5 Pa; c, the coolant is heated to 0 DEG C+/-1 DEG C, heat preservation is conducted, and gas infiltration is conducted till the vacuum degree reaches 25 Pa+/-5 Pa; d, the coolant is heated to 5 DEG C+/-1 DEG C, heat preservat</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language chi ; eng
recordid cdi_epo_espacenet_CN106581644A
source esp@cenet
subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Freeze-drying process of thymalfasin for injection
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T12%3A26%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LIU%20YUANZHENG&rft.date=2017-04-26&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN106581644A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true