Freeze-drying process of thymalfasin for injection

The invention discloses a freeze-drying process of thymalfasin for injection. The freeze-drying process is characterized by including the first step of pre-freezing, the second step of primary sublimation drying and the third step of secondary sublimation drying. In the second step of primary sublim...

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Bibliographische Detailangaben
Hauptverfasser:	LIU YUANZHENG, OUYANG JIAN, WANG LIANGYOU, GU SHIPING, SHEN YUNFENG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses a freeze-drying process of thymalfasin for injection. The freeze-drying process is characterized by including the first step of pre-freezing, the second step of primary sublimation drying and the third step of secondary sublimation drying. In the second step of primary sublimation drying, seven-stage step temperature rise is adopted, wherein a, a coolant is heated to -10 DEG C+/-1 DEG C, and heat preservation is conducted for 1-1.5 h; when the vacuum degree reaches 15 Pa+/-3 Pa, automatic pulsed gas infiltration is conducted, and when the vacuum degree reaches 25 Pa+/-5 Pa, gas infiltration is stopped; b, the coolant is heated to -5 DEG C+/-1 DEG C, heat preservation is conducted for 1-1.5 h, and gas infiltration is conducted till the vacuum degree reaches 25 Pa+/-5 Pa; c, the coolant is heated to 0 DEG C+/-1 DEG C, heat preservation is conducted, and gas infiltration is conducted till the vacuum degree reaches 25 Pa+/-5 Pa; d, the coolant is heated to 5 DEG C+/-1 DEG C, heat preservat