Content determination method of sodium ferulate, aspirin, cinnarizine and vitamin B1

The invention relates to a content determination method of sodium ferulate, aspirin, cinnarizine and vitamin B1 in compound sodium ferulate-aspirin capsules. The method comprises the following steps: using an octadecylsilane bonded silica gel as a filler and a phase A and a phase B as mobile phases,...

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Hauptverfasser: LIANG QIUHUA, XIANG SHUANG, FAN LINGLING, LI GAOZHAO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a content determination method of sodium ferulate, aspirin, cinnarizine and vitamin B1 in compound sodium ferulate-aspirin capsules. The method comprises the following steps: using an octadecylsilane bonded silica gel as a filler and a phase A and a phase B as mobile phases, wherein the phase A is a mixed solvent of acetonitrile, tetrahydrofuran, glacial acetic acid and water, the phase B is a mixed solvent of methanol, triethanolamine and triethylamine, and the pH value is 6.0-7.0; preparing a test sample solution, a mixed reference substance solution and a negative reference substance solution; and respectively absorbing 10 mu l of the test sample solution, mixed reference substance solution and negative reference substance solution, injecting into a liquid chromatograph, determining, recording the chromatogram, and calculating the percents of the compositions according to the peak area by an external standard process. The method has the advantages of short detection time and one-st