Chinese gall acid derivative having anticancer activity and application thereof

The invention provides a Chinese gall acid derivative having anticancer activity. A structural general formula is shown as a specification; wherein, R is an acid anhydrides functional group, and R2 is one of 1,3,5-trimethylaniline, 2,4-dimethylaniline, 1-hydroxybenzotriazole, 1-chlorobenzothiazole,...

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Bibliographische Detailangaben
Hauptverfasser: LI BENHAN, CHEN SHILIN, HUANG LINFANG, WEI WENLONG, YANG XIANYING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a Chinese gall acid derivative having anticancer activity. A structural general formula is shown as a specification; wherein, R is an acid anhydrides functional group, and R2 is one of 1,3,5-trimethylaniline, 2,4-dimethylaniline, 1-hydroxybenzotriazole, 1-chlorobenzothiazole, 3-skatole or 3-chloroindole functional group. The Chinese gall acid derivative has good activity for oral cancer cells, has strong selectivity, and has good clinical application value. 本发明提供了种具有抗癌活性的五倍子酸衍生物,其结构通式为:其中R1为酸酐官能基团,R2为1,3,5-三甲基苯胺、2,4-二甲基苯胺、1-羟基苯并三唑、1-氯代苯并三唑、3-甲基吲哚或3-氯吲哚官能基团中的种本发明提供的五倍子酸衍生物对口腔癌细胞具有良好的活性,且选择性强,具有良好的临床应用价值。