Purification process for preparation of 2,2-bis(2-thienyl)glycolic acid scopoletin

Purification process for preparation of 2,2-bis(2-thienyl)glycolic acid scopoletin

The invention relates to a purification process for preparation of a tiotropium bromide key intermediate, 2,2-bis(2-thienyl)glycolic acid scopoletin, represented as the formula (I), wherein purification steps are simplified and quality of yield of a product are increased. 本发明涉及种制备式（I）所示的噻托溴铵关键中间体2,2...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LOU JINFANG, CHEN JIAOYAN, SONG BOFAN, YE XINJIE, LUO JIN, HU FUMIAO
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a purification process for preparation of a tiotropium bromide key intermediate, 2,2-bis(2-thienyl)glycolic acid scopoletin, represented as the formula (I), wherein purification steps are simplified and quality of yield of a product are increased. 本发明涉及种制备式（I）所示的噻托溴铵关键中间体2,2-双(2-噻吩基)乙醇酸东莨菪酯的纯化工艺。简化了纯化步骤，提高了产品的质量和收率。