Axitinib fumarate, crystal form thereof and preparation methods for Axitinib fumarate and crystal form thereof

The invention relates to the technical field of medical chemistry and particularly relates to Axitinib fumarate, a crystal form thereof and preparation methods for the Axitinib fumarate and the crystal form thereof. The prepared Axitinib fumarate and the crystal form thereof are high in Axitinib fumarate yield and high in purity. In addition, the Axitinib fumarate provided by the invention can further be used for preparing Axitinib after the Axitinib fumarate is dissociated. According to the preparation method for the Axitinib fumarate, disclosed by the invention, the Axitinib fumarate is prepared through subjecting the Axitinib and fumaric acid to a salt forming reaction. The Axitinib may be a direct crude product prepared by disclosures in the existing documents, or may also be pure Axitinib which is obtained through carrying out certain-aftertreatment impurity removal. Even if crude Axitinib and fumaric acid are subjected to salt forming, the Axitinib fumarate with high purity can be prepared through the s