Compositions and methods for the treatment and prevention of antipsychotic medication-induced weight gain

The invention provides methods and compositions for the treatment of a subject having a psychiatric disease or disorder based upon the subject's genotype and/or the number of risk alleles carried by the subject, which risk alleles have been found by the present inventors to predispose a subject to antipsychotic medication induced weight gain (AIWG). The methods of the invention also provide for different treatments, or different treatment regimens, for the subject depending on the subject's risk of AIWG. Related compositions, in the form of kits, systems, and computer-readable media are also provided. 本发明提供基于患有精神疾病或紊乱的对象的基因型和/或所述对象携带的风险等位基因的数量，来治疗所述对象的方法和组合物，其中，本发明的发明人已发现该风险等位基因使所述对象倾向于抗精神病药物诱导的增重(AIWG)。还提供本发明的方法，所述方法根据所述对象的AIWG风险，用于针对所述对象的不同的治疗或不同的治疗方案。还提供相关的组合物，具有试剂盒、系统和计算机可读介质形式。