Triaging of patients having asymptomatic hematuria using genotypic and phenotypic biomarkers

New methods for identifying patents with hematuria who are at low risk of having urothelial cancer (UC) include combining selected phendtypic variables with levels of genotypic expression into a new metric, the "G+P INDEX." The G+P INDEX combines age, sex, smoking history, presence of hematuria, and frequency of hematuria with genotypic expression of the genetic markers, MDK, CDC2, HOXA13, IGFBP5, and optionally IL8Rb, then determining of the G+P INDEX value obtained for a patient is within one of three groups, either: (1) at High Risk of UC, (2) at Risk of UC, or (3) at Low Risk of UC. 用于识别低风险地具有尿路上皮癌(UC)的血尿患者的新方法，该方法包括将挑选的表型变量与基因型表达水平组合到新的指标，即"G+P指数"中。G+P指数将年龄、性别、吸烟史、血尿的存在和血尿的频率与遗传标志物，MDK、CDC2、HOXA13、IGFBP5和可选的IL8Rb的基因型表达相结合，然后确定由患者所获得的G+P指数值是在以下三组中的组内：(1)UC高风险，(2)UC风险，或(3)UC低风险。