2,2,2-trifluoroethyl-thiadiazines

The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylacti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	PETERS JENS-UWE, BARTELS BJOERN, HAAP WOLFGANG, OBST SANDER ULRIKE, ANSELM LILLI, DOLENTE COSIMO, ROGERS-EVANS MARK, GUBA WOLFGANG, WOLTERING THOMAS
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease. 本发明提供具有BACE1抑制活性的式(I)的化合物、其制备、包含其的药物组合物及其作为治疗活性物质的用途。本发明的活性化合物可用于治疗性和/或预防性治疗例如阿尔茨海默病。