Novel tyrosinase inhibitor

The application provides a novel tyrosinase inhibitor. Golden cassia tea is used as a raw material for extracting the tyrosinase inhibitor, and a condensed tannin extract is obtained by extracting, separating and purifying by the steps of acetone extraction, centrifugation, extraction, Sephadex LH-2...

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Hauptverfasser: SONG WEI, YANG HAIBO, WEI SHUDONG, LIU JING, SHE QIUSHENG, WANG KE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The application provides a novel tyrosinase inhibitor. Golden cassia tea is used as a raw material for extracting the tyrosinase inhibitor, and a condensed tannin extract is obtained by extracting, separating and purifying by the steps of acetone extraction, centrifugation, extraction, Sephadex LH-20 column chromatography, and the like. The extract is prepared from procyanidine, a homopolymer formed by propelargonidin and prodelphinidins, and a heteropolymer, wherein the procyanidine is taken as a main component. The extract has an obvious inhibitory influence effect on the activity of tyrosinase, and has the half inhibition rate of 54.8+/-1.27mu g/mL; the inhibition type of the extract is reversible inhibition, and the inhibition mechanism of the extract is in a hybrid type. The tyrosinase inhibitor provided by the application is convenient in material obtaining, low in price and simple and convenient to operate, thus having wide application prospect in the fields such as medical cosmetology, fruit and veget