Detection markers for cholesterol metabolism and application of same in assessment of curative effect of drugs used for treating cardio-cerebrovascular diseases

The invention discloses detection markers for cholesterol metabolism and application of the same in assessment of the curative effect of drugs used for treating cardio-cerebrovascular diseases. Research results show that 7-alkenyl cholesterin, desmosterol, campesterol and beta-sitosterol can be used as markers for detection of the conditions of cholesterol metabolism and precise determination of the dynamic situation of absorption and in-vivo synthesis of cholesterol. Detection results can provide doctors with bases for formulation of a precise treatment scheme for patients, guide medication and improve treatment effect, so the markers have substantial clinical significance. 本发明公开了胆固醇代谢检测标志物及其在评估心脑血管疾病药物疗效中的应用。本发明通过研究发现7-烯胆甾醇、链甾醇、菜油固醇和β-谷固醇可作为检测胆固醇代谢状况的标志物，可精准测定胆固醇的吸收和胆固醇的体内合成动态情况；检测结果可以为医生提供制定病人精准治疗的依据，提导用药，提高治疗效果，有显著临床意义。