Preparation method for (2R)-5-methoxy-1,2,3,4-tetrahydro-2-naphthol

The invention discloses a preparation method for (2R)-5-methoxy-1,2,3,4-tetrahydro-2-naphthol. The preparation method provided by the invention comprises the following steps: with 5-methoxy-2-tetralone as a raw material, carrying out hydrogenation reduction so as to obtain 5-methoxy-1,2,3,4-tetrahydro-2-naphthol; and then with p-chlorophenol acetate as an acyl group donor, porcine pancreatic lipase (PPL) as a resolution catalyst and acidic resin D006 as a racemization catalyst, carrying out dynamic kinetic resolution so as to obtain (2R)-5-methoxy-1,2,3,4-tetrahydro-2-naphthol. The method has the characteristics of simple operation, high product yield, good optical purity of the product, etc., and is of great guidance and application value to production of and research on (2R)-5-methoxy-1,2,3,4-tetrahydro-2-naphthol. 本发明公开了种(2R)-5-甲氧基-1,2,3,4-四氢-2-萘酚的制备方法。以5-甲氧基-2-萘满酮为原料，加氢还原得5-甲氧基-1,2,3,4-四氢-2-萘酚，再以对氯苯酚乙酸酯为酰基供体，猪胰脂肪酶PPL为拆分催化剂，酸性树脂D006为消旋催化剂进行动态动学拆分得(2R)-5-甲氧基-1,2,3,4-四氢-2-萘酚。本方法具备操作简单，产品收率高、光学纯度好等特点，在(2R)-5-