Preparation method of R-7-chloro-1-tetralinylamine

Preparation method of R-7-chloro-1-tetralinylamine

The invention discloses a preparation method of R-7-chloro-1-tetralinylamine. The method comprises the following steps: carrying out reduction ammonification reaction on the raw material 7-chloro-1-tetralone to obtain 7-chloro-1,2,3,4-tetrahydronaphthyl-1-amine, and carrying out dynamic kinetic reso...

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Bibliographische Detailangaben
1. Verfasser: WANG JIJU
Format: Patent
Sprache:chi ; eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention discloses a preparation method of R-7-chloro-1-tetralinylamine. The method comprises the following steps: carrying out reduction ammonification reaction on the raw material 7-chloro-1-tetralone to obtain 7-chloro-1,2,3,4-tetrahydronaphthyl-1-amine, and carrying out dynamic kinetic resolution on the 7-chloro-1,2,3,4-tetrahydronaphthyl-1-amine by using the combination of lipase and a racemization catalyst to obtain the R-7-chloro-1,2,3,4-tetrahydronaphthyl-1-amine. The method is simple to operate, and has the characteristics of wide raw material sources, favorable product yield, high optical purity of the resolution product and the like. 本发明公开了种R-7-氯-1-萘满胺的制备方法，本发明的具体方法是以7-氯-1-萘满酮为原料，经还原氨化反应得7-氯-1,2,3,4-四氢萘-1-胺，7-氯-1,2,3,4-四氢萘-1-胺再由脂肪酶与消旋催化剂结合进行动态动力学拆分得R-7-氯-1,2,3,4-四氢萘-1-胺。本发明具备操作简单、原料来源广、产品收率好、拆分产品光学纯度高等特点。