Method for preparing cefotiam hexetil hydrochloride

The invention discloses a method for preparing cefotiam hexetil hydrochloride. The method comprises the following steps: preparing cefotiam hexetil free alkali through choride iodination and one-pot esterification method by taking stable raw materials such as cefotiam hexetil hydrochloride and chlorinated carbonate as initial materials; performing low-temperature concentration, devitrification and other processes, thereby obtaining the purified cefotiam hydrochloride free alkali; and finally, carrying out a hydrochloride formation reaction, thereby obtaining the cefotiam hexetil hydrochloride. The method has the characteristics of high reaction stability and controllability, low product impurity content, simplicity in industrialized production and the like. 本发明公开了种盐酸头孢替安酯的制备方法，采用稳定的原料盐酸头孢替安酯以及氯代碳酸酯为起始原料，通过氯代物碘代、酯化锅法制备头孢替安酯游离碱，再通过低温浓缩、析晶等工艺，得到纯化的盐酸头孢替安游离碱，最后通过成盐酸盐反应得到盐酸头孢替安酯。该方法具有反应稳定性和可控性高，产物杂质低，易于工业化生产等特点。