Method for synthesizing 4-(2-aminoethyl)benzsulfamide

The invention aims at solving the technical problem of providing a method for synthesizing 4-(2-aminoethyl)benzsulfamide, and beta-phenylethylamine is used as a raw material, and is subjected to an acetylation reaction, a chlorosulfaonationreaction, an amination reaction, a hydrolysis reaction and p...

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Hauptverfasser: CAI YONGHONG, JIANG JINREN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention aims at solving the technical problem of providing a method for synthesizing 4-(2-aminoethyl)benzsulfamide, and beta-phenylethylamine is used as a raw material, and is subjected to an acetylation reaction, a chlorosulfaonationreaction, an amination reaction, a hydrolysis reaction and purification to obtain the finished product 4-(2-aminoethyl)benzsulfamide. The method has the effects of being easily available in raw materials, low in cost, small in amount of chlorosulfonic acid in the chlorosulfaonation reaction, less in wastewater quantity, high in production yield, recyclable in by-products and beneficial to popularization and application. The product prepared by the method can be used in the synthesis and production of sulfonylurea hypoglycemic drugs, such as glipizide, glimepiride, gliquidone and glibenclamide. According to the method, cheap chemical materials are adopted, the reaction is simple and easy to operate, the problems of expensive raw materials and difficult operation of the react