Quinazoline compound and its intermediate, preparation method, pharmaceutical composition and use
The invention discloses a quinazoline compound and its intermediate, preparation method, pharmaceutical composition and use. The quinazoline compound has good effects of inhibiting protein kinase JAK and can be used for preparing drugs for preventing, treating or assistantly treating a plurality of...
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| creator | WANG WANHE ZHOU QIAN ZHANG DAPENG ZHANG CHUNLING WANG YUJI XIA GUANGXIN ZHANG YONG ZHENG LIANYOU YU JIANXIN BAI XU |
| description | The invention discloses a quinazoline compound and its intermediate, preparation method, pharmaceutical composition and use. The quinazoline compound has good effects of inhibiting protein kinase JAK and can be used for preparing drugs for preventing, treating or assistantly treating a plurality of diseases related to JAK expression or activity and especially for preparing drugs for treating tumor diseases and immunological diseases.
本发明公开了种喹唑啉类化合物、其中间体、制备方法、药物组合物和应用。本发明的喹唑啉类化合物对蛋白激酶JAK有良好地抑制效果，可以用于制备预防、治疗或辅助治疗与JAK的表达或活性有关的多种疾病，尤其是肿瘤疾病和免疫疾病的药物。 |
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本发明公开了种喹唑啉类化合物、其中间体、制备方法、药物组合物和应用。本发明的喹唑啉类化合物对蛋白激酶JAK有良好地抑制效果，可以用于制备预防、治疗或辅助治疗与JAK的表达或活性有关的多种疾病，尤其是肿瘤疾病和免疫疾病的药物。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjL0KAjEQhNNYiPoOsVfwOAxYyqFYCYL9sSQrt5BsQrJpfHrjzwNYDAPDN99cwa0SwzN6YtQ2hhQrOw0tJEUTC-aAjkBwo1PGBBmEIuuAMkXXtglyAItVyIL_Ggp9kLekFlyq2QN8wdWvF2p9Pt2HyxZTHLGkdmaUcbh2O9N35mD2x_4f5gV5yj55</recordid><startdate>20170111</startdate><enddate>20170111</enddate><creator>WANG WANHE</creator><creator>ZHOU QIAN</creator><creator>ZHANG DAPENG</creator><creator>ZHANG CHUNLING</creator><creator>WANG YUJI</creator><creator>XIA GUANGXIN</creator><creator>ZHANG YONG</creator><creator>ZHENG LIANYOU</creator><creator>YU JIANXIN</creator><creator>BAI XU</creator><scope>EVB</scope></search><sort><creationdate>20170111</creationdate><title>Quinazoline compound and its intermediate, preparation method, pharmaceutical composition and use</title><author>WANG WANHE ; ZHOU QIAN ; ZHANG DAPENG ; ZHANG CHUNLING ; WANG YUJI ; XIA GUANGXIN ; ZHANG YONG ; ZHENG LIANYOU ; YU JIANXIN ; BAI XU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN106316965A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WANG WANHE</creatorcontrib><creatorcontrib>ZHOU QIAN</creatorcontrib><creatorcontrib>ZHANG DAPENG</creatorcontrib><creatorcontrib>ZHANG CHUNLING</creatorcontrib><creatorcontrib>WANG YUJI</creatorcontrib><creatorcontrib>XIA GUANGXIN</creatorcontrib><creatorcontrib>ZHANG YONG</creatorcontrib><creatorcontrib>ZHENG LIANYOU</creatorcontrib><creatorcontrib>YU JIANXIN</creatorcontrib><creatorcontrib>BAI XU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WANG WANHE</au><au>ZHOU QIAN</au><au>ZHANG DAPENG</au><au>ZHANG CHUNLING</au><au>WANG YUJI</au><au>XIA GUANGXIN</au><au>ZHANG YONG</au><au>ZHENG LIANYOU</au><au>YU JIANXIN</au><au>BAI XU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Quinazoline compound and its intermediate, preparation method, pharmaceutical composition and use</title><date>2017-01-11</date><risdate>2017</risdate><abstract>The invention discloses a quinazoline compound and its intermediate, preparation method, pharmaceutical composition and use. The quinazoline compound has good effects of inhibiting protein kinase JAK and can be used for preparing drugs for preventing, treating or assistantly treating a plurality of diseases related to JAK expression or activity and especially for preparing drugs for treating tumor diseases and immunological diseases.
本发明公开了种喹唑啉类化合物、其中间体、制备方法、药物组合物和应用。本发明的喹唑啉类化合物对蛋白激酶JAK有良好地抑制效果，可以用于制备预防、治疗或辅助治疗与JAK的表达或活性有关的多种疾病，尤其是肿瘤疾病和免疫疾病的药物。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Quinazoline compound and its intermediate, preparation method, pharmaceutical composition and use |
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