Quinazoline compound and its intermediate, preparation method, pharmaceutical composition and use

Quinazoline compound and its intermediate, preparation method, pharmaceutical composition and use

The invention discloses a quinazoline compound and its intermediate, preparation method, pharmaceutical composition and use. The quinazoline compound has good effects of inhibiting protein kinase JAK and can be used for preparing drugs for preventing, treating or assistantly treating a plurality of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WANG WANHE, ZHOU QIAN, ZHANG DAPENG, ZHANG CHUNLING, WANG YUJI, XIA GUANGXIN, ZHANG YONG, ZHENG LIANYOU, YU JIANXIN, BAI XU
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention discloses a quinazoline compound and its intermediate, preparation method, pharmaceutical composition and use. The quinazoline compound has good effects of inhibiting protein kinase JAK and can be used for preparing drugs for preventing, treating or assistantly treating a plurality of diseases related to JAK expression or activity and especially for preparing drugs for treating tumor diseases and immunological diseases. 本发明公开了种喹唑啉类化合物、其中间体、制备方法、药物组合物和应用。本发明的喹唑啉类化合物对蛋白激酶JAK有良好地抑制效果，可以用于制备预防、治疗或辅助治疗与JAK的表达或活性有关的多种疾病，尤其是肿瘤疾病和免疫疾病的药物。