Application of 7,8-dihydroxyflavone (DHF) to preparation of drug for treating retinal degenerative diseases

The invention belongs to the pharmaceutical field and relates to an application of 7,8-dihydroxyflavone (DHF) to preparation of a drug for treating retinal degenerative diseases. Through adult SD rat optic nerve contusion model experiments, the results show that 7,8-DHF can achieve the effects of re...

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Hauptverfasser: MAIERHABA XIAOKAITI, XIONG JIAWEI, MO XIAOFEN, RONG XIANFANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the pharmaceutical field and relates to an application of 7,8-dihydroxyflavone (DHF) to preparation of a drug for treating retinal degenerative diseases. Through adult SD rat optic nerve contusion model experiments, the results show that 7,8-DHF can achieve the effects of reducing apoptosis of retinal ganglion cells and increasing the survival rate and has obvious protective effects on injured retinal neurons. 7,8-DHF is used for further treating the retinal degenerative diseases by protecting the injured retinal neurons, wherein the retinal degenerative diseases include glaucoma, macular degeneration, retinitis pigmentosa, ischemic optic neuropathy and traumatic optic nerve contusion. The invention also provides a novel small molecular drug preparation with 7,8-DHF as the main active ingredient. Obvious protective effects can be generated for the injured retinal neurons by locally delivering the drug to the vitreous cavities of eyes. 本发明属于制药领域,涉及7,8-二羟基黄酮在制备治疗视网膜变性性疾病药物中的用途。本发明通过成年SD