Method for preparing naringenin/hydroxypropyl-Beta-cyclodextrin microcapsules by supercritical anti-solvent process

The invention discloses a method for preparing naringenin/hydroxypropyl-Beta-cyclodextrin microcapsules by supercritical anti-solvent process, comprising the steps of S1, dissolving naringenin and hydroxypropyl-Beta-cyclodextrin in an organic solvent to obtain a sample solution; S2, introducing CO2...

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Hauptverfasser: WANG WEIYAN, WANG ZHIXIANG, SONG YAQIN, CHEN ZHEN, XU WENBO, GAO ZHAOHUA, LIU SHANGDE, MIAO HONGGANG
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creator WANG WEIYAN
WANG ZHIXIANG
SONG YAQIN
CHEN ZHEN
XU WENBO
GAO ZHAOHUA
LIU SHANGDE
MIAO HONGGANG
description The invention discloses a method for preparing naringenin/hydroxypropyl-Beta-cyclodextrin microcapsules by supercritical anti-solvent process, comprising the steps of S1, dissolving naringenin and hydroxypropyl-Beta-cyclodextrin in an organic solvent to obtain a sample solution; S2, introducing CO2 into a crystallizer, and adjusting temperature and pressure in the crystallizer; S3, continually introducing CO2 at a flow speed, maintaining the temperature and pressure in the crystallizer constant, and introducing the sample solution of step S1 into the crystallizer; S4, after introduction of the sample solution, continuously introducing CO2, maintaining the temperature and pressure in the crystallizer constant, and relieving the pressure over a period of time; when the pressure in the crystallizer drops to atmospheric pressure, opening the crystallizer to collect the naringenin/hydroxypropyl-Beta-cyclodextrin microcapsules. The method provided herein wraps naringenin in HP-Beta-CD by using supercritical anti-so
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Method for preparing naringenin/hydroxypropyl-Beta-cyclodextrin microcapsules by supercritical anti-solvent process
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