Method for preparing naringenin/hydroxypropyl-Beta-cyclodextrin microcapsules by supercritical anti-solvent process

The invention discloses a method for preparing naringenin/hydroxypropyl-Beta-cyclodextrin microcapsules by supercritical anti-solvent process, comprising the steps of S1, dissolving naringenin and hydroxypropyl-Beta-cyclodextrin in an organic solvent to obtain a sample solution; S2, introducing CO2 into a crystallizer, and adjusting temperature and pressure in the crystallizer; S3, continually introducing CO2 at a flow speed, maintaining the temperature and pressure in the crystallizer constant, and introducing the sample solution of step S1 into the crystallizer; S4, after introduction of the sample solution, continuously introducing CO2, maintaining the temperature and pressure in the crystallizer constant, and relieving the pressure over a period of time; when the pressure in the crystallizer drops to atmospheric pressure, opening the crystallizer to collect the naringenin/hydroxypropyl-Beta-cyclodextrin microcapsules. The method provided herein wraps naringenin in HP-Beta-CD by using supercritical anti-so