Quetiapine hemifumarate synthesis technology

The invention discloses a quetiapine hemifumarate synthesis technology. The technology comprises the following steps: mixing a compound of formula (II) and C1-C4 alkyl acid, heating the compound of formula (II) and the C1-C4 alkyl acid to 80-100 DEG C, adding zinc powder or iron powder, and carrying out a heat insulation reaction for 4-6 h to obtain quetiapine; and carrying out salt formation on the obtained quetiapine and fumaric acid to obtain quetiapine hemifumarate, wherein a feeding molar ratio of quetiapine to fumaric acid is 1:0.5. The technology has the advantages of simplicity in operation, high yield, high purity of the above obtained product, and easy realization of industrialization. 本发明公开了种半富马酸喹硫平的合成工艺，包括如下步骤：将式(II)化合物、C1-C4烷酸混合，并升温至80-100℃，加入锌粉或铁粉，保温反应4-6h，得喹硫平；将所得的喹硫平与富马酸成盐，得半富马酸喹硫平，其中，喹硫平与富马酸投料的摩尔比为1:0.5。本发明的工艺具有操作简便、收率高，所得产品纯度高等优势，且易于实现工业化。