Preparation method of BOC-L-asparagine

The invention discloses a preparation method of BOC-L-asparagine. The preparation method comprises the following steps: using L-asparaginate and di-tert-butyl dicarbonate ester as raw materials and water as a reaction solvent to carry out a reaction under the alkaline condition of pH 9-10 to generate BOC-L-asparagine, acidizing a reaction liquid to pH 4.0-4.5 to precipitate out a BOC-L-asparagine crude product, carrying out suction filtration, washing with water and drying to obtain a BOC-L-asparagine refined product. The preparation method of BOC-L-asparagine has advantages of mild reaction condition, fast reaction and lower cost of raw materials. As water is used as the reaction solvent, the subsequent operation is simple, and BOC-L-asparagines crystal can be precipitated out only by acidifying. The method is beneficial to industrial production, is environment friendly and has high safety factor. 本发明公开了种BOC-L-天门冬酰胺的制备方法，以L-天冬酰胺和二碳酸二叔丁酯为原料，以水为反应溶剂，在pH 9～10的碱性条件下反应生成BOC-L-天门冬酰胺，反应液酸化至pH 4.0～4.5析出BOC-L-天门冬酰胺粗品