Tilmicosin inclusion compound chitosan temperature-sensitive gel and preparation method thereof

The invention belongs to the field of chemical synthesis, and particularly relates to tilmicosin inclusion compound chitosan temperature-sensitive gel and a preparation method thereof. The preparation method includes the steps: weighing chitosan, dissolving the chitosan in 0.1mol/L hydrochloric acid and sufficiently stirring the hydrochloric acid until completely dissolving the chitosan; dissolving sodium glycerophosphate in deionized water; dripping sodium glycerophosphate solution into chitosan solution; adjusting the pH (potential of hydrogen) value of mixed solution; uniformly stirring the obtained mixed solution at the temperature of 4 DEG C to obtain chitosan temperature-sensitive gel; weighing a tilmicosin inclusion compound in a conical flask; adding an appropriate amount of chitosan temperature-sensitive gel into the conical flask and uniformly stirring the tilmicosin inclusion compound and the chitosan temperature-sensitive gel in a magnetic stirrer at normal temperature to obtain the tilmicosin inc