Tigecycline pharmaceutical composition and preparing method thereof

The invention relates to a tigecycline pharmaceutical composition and a preparing method thereof, in particular to a stable tigecycline composition and a preparing method for improving stability of the composition. The composition is prepared from 1 part of tigecycline, 0.5-5 parts of lactose, 0.15-...

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Hauptverfasser: LYU HUI, ZHUANG XUGUO, JIANG TAO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a tigecycline pharmaceutical composition and a preparing method thereof, in particular to a stable tigecycline composition and a preparing method for improving stability of the composition. The composition is prepared from 1 part of tigecycline, 0.5-5 parts of lactose, 0.15-0.35 part of hydrochloric acid and 0.025-0.5 part of vitamin C. The preparing method includes the steps that lactose and vitamin C are dissolved with water for injection, the solution is filtered for decarburization after activated carbon adsorption, after the solution is cooled, tigecycline is added and mixed uniformly, and the volume is set after adding hydrochloric acid. A penicillin bottle is filled with liquid medicine filter core after the filter core is filtered, filling, half plugging, plate loading and freeze-drying are carried out, and the freeze-drying stage includes a pre-freezing stage, an annealing stage, a sublimating stage and an after-drying stage. The finished product obtained by adopting the comp