Liquid vehicle for suspension of undelivered particles

The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets. Additionally or optionally, there is a step of applying a sufficient amount of a liquid to the treatment area after substantial evaporation of the formulation leaves a particle residue on the skin surface. Thereafter, one or more steps of facilitating delivery of particles into a portion of the skin are repeated. Finally, the particles are exposed to a suitable energy activation, thereby providing the desired treatment or clinical outcome. 本发明提供包括吸能(例如光)亚微米颗粒(例如包括二氧化硅核和金壳的纳米颗粒)的组合物和通过局部施用输送这些颗粒的方法。该输送通过机械搅动(如按摩)、10Hz-20kHz范围内的声振动、超声、交替吸力和压力和微射流促进。另外地或任选地，在制剂大量蒸发在皮肤表面留下颗粒残余物之后，施用足够量的液体至治