6-amino-4(3H)-quinazolinone derivatives and their synthesis method and use

The invention discloses 6-amino-4(3H)-quinazolinone derivatives and their synthesis method and use and belongs to the technical field of drug synthesis. The invention also relates to a use of the 6-amino-4(3H)-quinazolinone derivatives with a general formula (I) and its synthesis method in medical science, wherein in the general formula (I), X represents (CH2)n-1, n=1 to 10 and R1, R2 and R3 represent different substituents. The invention discloses the compound structures and their synthesis method and external acetylcholinesterase inhibition activity. The 6-amino-4(3H)-quinazolinone derivatives can be further studied and developed to form novel drugs for treating Alzheimer disease. 6-氨基-4(3H)-喹唑啉酮衍生物及其合成方法和用途，本发明属药物合成技术领域，涉及通式(I)为：X为(CH)，n＝1-10；涉及通式(I)R，R，R为不同取代基的6-氨基-4(3H)-喹唑啉酮衍生物及其合成方法在医学上的应用。本发明公开了这些化合物结构和合成方法及体外乙酰胆碱酯酶抑制活性，可进步研制开发成为治疗阿尔茨海默病的新型药物。