Naphthoquinone derivative containing adamantyl and preparation method and application of derivative

The invention provides a naphthoquinone derivative containing adamantyl and a preparation method and application of the derivative, and particularly provides a naphthoquinone derivative which is as shown in a following formula (I) and contains adamantyl, wherein definitions of all groups are describ...

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Bibliographische Detailangaben
Hauptverfasser:	YANG CAIGUANG, ZHANG AO, NI TENGFENG, WANG MEINING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides a naphthoquinone derivative containing adamantyl and a preparation method and application of the derivative, and particularly provides a naphthoquinone derivative which is as shown in a following formula (I) and contains adamantyl, wherein definitions of all groups are described in the description. The compound has Sortase A enzyme inhibitory activity and cytotoxic activity and can be used for treating diseases related to Sortase A enzyme and various malignant tumors. Please see the formula (I) in the description. 本发明提供了种含金刚烷基的萘醌类衍生物、其制备方法及应用，具体地，本发明提供了种如下式(I)所示的含金刚烷基的萘醌类衍生物。其中，各基团的定义如说明书中所述。本发明化合物具有Sortase A酶抑制活性及细胞毒活性，且可以用于治疗Sortase A酶活性相关的疾病及各种恶性肿瘤。